chapter13 - Lecture Outline Cardboard Atoms and Bent-Wire...

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Lecture Outline Cardboard Atoms and Bent-Wire Bonds A. Johann Friedrich Miescher discovered nucleic acids in 1868. B. Linus Pauling discovered the helical structure of proteins in 1951. C. In 1953, Watson and Crick discovered the structure of the master molecule of life--DNA. 13.1 Discovery of DNA Function A. Early and Puzzling Clues 1. In 1928, Fred Griffith was working with S (pathogenic) and R (nonpathogenic) strains of a pneumonia-causing bacterium. 2. He performed four experiments summarized here: a. Inject mice with R cells; mice lived. b. Inject mice with S cells; mice died; blood samples contained many live S cells. c. S cells were heat-killed then injected into mice; mice lived. d. Live R cells plus heat-killed S cells were injected into mice; mice died; live S cells were found in the blood. 3. Some substance from the S cells had transformed the R cells. a. Both proteins and nucleic acids were candidates. b. In 1944, Oswald Avery showed that the substance was DNA.
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chapter13 - Lecture Outline Cardboard Atoms and Bent-Wire...

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