January 27 Lecture - White Blood Cells Leukocytes True...

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January 27, 2009 White Blood Cells - Leukocytes - True cells – contain a nucleus unlike erythrocyte - White blood cells are not red, they do not contain haemoglobin - White blood cells range from 5,000-10,000/m 3 of whole blood under normal conditions - If the individuals are under emotional stress, pain, may increase WBC count by 5-10 fold - Greater increases can occur by 100x in pathological instances - There are several types of white blood cells o Lymphocyte Agranular Originate in the bone marrow and migrate and mature (complete development) within lymphatic tissues Tonsil tissue, thymus, spleen, the lymph nodes, and the mucosal layer of the intestines are all involved in the maturation of lymphocytes o Monocyte Agranular Develop in bone marrow and blood vascular tissue and they complete their maturation process (and turn into macrophages – which allows them to move from the blood stream into peripheral tissues o Granulocytes Basophil Formed from myeloblasts in red bone marrow Something about embryonic cells Eosinophil Formed from myeloblasts in red bone marrow Neutrophil Formed from myeloblasts in red bone marrow - Platelets o Not cells at all o Also known as thrombocytes o Develop from megakaryocytes in the red bone marrow o Basically cell fragmentation o Important in blood clotting o Formed by growth of megakaryocytes, little portions of cytoplasm are split off - Bone marrow is a very important tissue in the body, gives rise to important cells (erythrocytes and leukocytes) - Cancers like leukemia often effects the bone marrow, anemia occurs, and so the rate of white blood cell production is impaired and eventually reduce erythrocyte and leukocyte counts occur - In normal healthy individuals, the number of erythrocytes and leukocytes being produced is approximately at an equal rate - Low leukocyte count in blood stream because:
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o Most leukocytes are not located in the blood stream, they are very mobile and make their way out of the blood vascular system via the interstitial fluids to peripheral areas of the body o Leukocytes also have a very short lifespan (ranges from a few hours to 10-12 hours, some may last a month) Still small compared to erythrocyte - Conditions that adversely affect leukocyte counts o Exposure to heat or cold for long periods of time o Worry o Loss of sleep o Alcoholism o Types of wasting diseases (diabetes, cancer) o Malnutrition If malnutrition involves lack of vitamins and amino acids - Role of leukocytes o Mobile defense system Bring about phagocytosis upon foreign molecules in the body
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This note was uploaded on 10/23/2011 for the course BIOL 2125 taught by Professor Dr.park during the Winter '02 term at A.T. Still University.

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January 27 Lecture - White Blood Cells Leukocytes True...

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