Chapter 5 - Cell Receptors

Chapter 5 - Cell Receptors - Cell receptors Cell...

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Cell receptors Cell communication - Cells must interact with their environment - Cells in multicellular organisms must coordinate activities o Act as a single unit: a tissue or an organ - Communication between cells requires: o Ligand: the signaling molecule (yup, I got the signal) o Receptor protein: the molecule to which the receptor binds (the receiver of the signals) - Ligand-receptor binding conveys information o Causes a response through signal transduction (transmitting a signal) Four mechanisms - Direct contact Paracrine signaling Endocrine signaling
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Synaptic signaling Signal transduction Cellular response
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Receptor types Intracellular receptors Steroid hormones as signals
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Types of membrane receptors Channel linked receptors Enzyme receptors
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Kinase cascades G-protein coupled receptors - G-protein-coupled receptor (GPCRs) – membrane receptors bound to G proteins - G-protein – binds to GTP/GDP, composed of three peptide subunits, a, b, y o Inactive when bound to GDP o Active when bound to GTP
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Chapter 5 - Cell Receptors - Cell receptors Cell...

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