Cont. Ch. 6 Notes - Bio 111 Lecture 8 after exam 1 Pattern...

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Pattern Formation: Gap genes -Position information leads to changes in gene activity and thus cells adopt a fate appropriate for their location -Body plan is produced by sequential activation of 3 classes of segmentation genes 1. Gap genes -establish body regions along A/P axis -also act as transcription factors that activate the next gene class 2. Pair-rule genes -subdivide gap-gene regions into 7 zones 3. Segment polarity genes -finish dividing and defining zones -subdivide the seven zones -work through induction Segment Identity -Identity of segments determined by action of homeotic genes -Mutations in them will lead to normal body parts in unusual places -Antennapedia mutants grow legs out of head where antenna should be Hox Genes -Homeotic gene complexes -All of these genes contain a conserved 180 base sequence -Encodes a 60 amino acid DNA binding domain, the homeodomain -Specify the identity of a body part in a location-dependent manner -Vertebrates have 4 Hox gene clusters
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This note was uploaded on 10/24/2011 for the course BIOL 111 taught by Professor Dr.zielinski during the Spring '08 term at Purdue University-West Lafayette.

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Cont. Ch. 6 Notes - Bio 111 Lecture 8 after exam 1 Pattern...

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