Lecture 6

Lecture 6 - Lecture 6 Cellular Mechanisms of Development...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
2 Lecture 6 Cellular Mechanisms of Development Overview of development o Development is the successive process of planned, gene-directed changes throughout an organism’s life cycle o Four processes bring about the changes: Cell division and cleavage Differentiation Pattern formation Morphogenesis Morphogens o Morphogens Molecules that affect developmental fate Initiate and terminate the four processes Bring about cell determination Can be proteins, mRNAs, or other molecules o Obtained in a couple of different ways: Inherited in cytoplasm from the egg: cytoplasmic determinants Received as signals from other cells: induction agents Cytoplasmic determinants o Deposited in egg cytoplasm during oogenesis Cytoplasm contains many different determinant Each is localized to a particular part of the egg Cells inherit a portion of the egg cytoplasm; thus, different sets of cytoplasmic determinants Puts cells on different developmental trajectories Especially active early in development Induction o Induction influences the fate of a cell due to interaction with nearby cells o Certain embryonic cells produce signaling proteins These are secreted into ECM Spread to nearby cells Are stage-specific
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 o Concentration highest near cells that secrete it Induce a concentration-dependent response
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

Lecture 6 - Lecture 6 Cellular Mechanisms of Development...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online