Lecture 6

Lecture 6 - Lecture 6 Cellular Mechanisms of Development...

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2 Lecture 6 Cellular Mechanisms of Development Overview of development o Development is the successive process of planned, gene-directed changes throughout an organism’s life cycle o Four processes bring about the changes: Cell division and cleavage Differentiation Pattern formation Morphogenesis Morphogens o Morphogens Molecules that affect developmental fate Initiate and terminate the four processes Bring about cell determination Can be proteins, mRNAs, or other molecules o Obtained in a couple of different ways: Inherited in cytoplasm from the egg: cytoplasmic determinants Received as signals from other cells: induction agents Cytoplasmic determinants o Deposited in egg cytoplasm during oogenesis Cytoplasm contains many different determinant Each is localized to a particular part of the egg Cells inherit a portion of the egg cytoplasm; thus, different sets of cytoplasmic determinants Puts cells on different developmental trajectories Especially active early in development Induction o Induction influences the fate of a cell due to interaction with nearby cells o Certain embryonic cells produce signaling proteins These are secreted into ECM Spread to nearby cells Are stage-specific
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2 o Concentration highest near cells that secrete it Induce a concentration-dependent response
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This note was uploaded on 10/24/2011 for the course BIOL 111 taught by Professor Dr.zielinski during the Spring '08 term at Purdue.

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Lecture 6 - Lecture 6 Cellular Mechanisms of Development...

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