02Lect_DevelopI_Updated_Allan - September 09/2011 Early...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Early Development Douglas Allan ([email protected]) Early Development Pgs. 478-482 in second edi±on Notes and fgures on website Many images From “Human Embryology” 3 rd Ed. (Larsen). Today: Developmental Concepts and Histology oF the Implanted Embryo Monday: ³orma±on oF primary germ layers (gastrula±on) and nervous system (neurula±on) September 09/2011
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Four Basic Tissues Epithelium (covers surfaces) Nervous Assue Muscle Assue ConnecAve Assue (supports other Assues) Organs are derived from 2 or more basic Assues. Basic Assues arise from three primary germ layers (ectoderm, mesoderm, endoderm).
Background image of page 2
Developmental concepts Differentiation- refers to the development of specialized cell types. That is, a cell becomes specialized for a specific function. Potency- refers to the possible cell types that a specific cell can generate during normal development. Totipotent - can give rise to any cell type. Pluripotent - can give rise to numerous cell types. Stem cells - these are cells that can create more stem cells (self renew) as well as differentiate into other cell types (potency).
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Rule of thumb- progression to a more diFerenAated state results in less potency Experimental basis - cloning
Background image of page 4
Test of potency: cloning frogs 1950’s/60’s Experiment Parents of donor (albino) Host One donor (albino tadpole)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Methodology: The experiment Oocyte (egg) Egg Host Nuclear Donor
Background image of page 6
Methodology: frog development
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The outcome As a cell diferen±ates, it becomes less ‘potent’ but retains all gene±c material
Background image of page 8
And then, Dolly! Cloned from adult cells
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/24/2011 for the course CHEMISTRY chem taught by Professor David during the Spring '11 term at The University of British Columbia.

Page1 / 29

02Lect_DevelopI_Updated_Allan - September 09/2011 Early...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online