UC Extension Org/BioChem X402 Final exam, 5/15/06.
Total points: 25
Some Figures are provided. You may use your (one) page of notes. Otherwise, “closed
book”: no models, books, other notes, or periodic table.
If a question isn’t clear, please ask me about it.
In a multi-part question, if a difficulty with one part is keeping you from continuing,
please check with me. If later parts depend on a structure you drew, you might have me
look over the structure.
Some questions request a simple answer and
an explanation. It’s the explanation that is
important. No credit for answer without a requested explanation.
When you are asked to mark something, please do so clearly, and label it clearly.
In naming compounds, IUPAC names are preferred, but valid common names will be
accepted. (A name will be graded based on the compound you show.)
Unless specifically noted, chemical equations need not be balanced. Equations should
show which chemicals are involved, both as reactants and major products. If no reaction is
expected, say so.
Electronegativies: H 2.1; C 2.5; O 3.5; S 2.5.
. (1 pt.)
One of the enzymes coded for by influenza virus is an RNA-dependent RNA
polymerase, used for replicating the genome. PB2 is one of the polymerase subunits. Amino
acid #627 of PB2 is glutamic acid in avian flu viruses, but lysine in flu viruses that can
replicate well in mammals. Describe this amino acid variation in terms of its effect on the
charge of the protein. (Be specific.)
. (3 pts.)
Linoleic acid is the major polyunsaturated acid in the fat we consume. In the body,
some of it gets oxidized to 13-hydroxy-9,11-octadecadienoic acid. The parts below refer to
this oxidation product.
a. (1 1/2 pts.) Draw the structure of this oxidation product.
b. (1/2 pt.) What is rather odd about this oxidation product? (Accept that the 13-hydroxy is
c. (1 pt.; no credit without explanation) Consider this oxidation product and the original
compound. Which one
is, in general, more suitable for use in membranes? Explain
general considerations about how biological membranes are organized.