This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: chlorides react with R 2 CuLi Rxn. of Organometallic Reagents with Other Compounds (20.14) • Grignard reagents react with CO 2 followed by H 3 O + to yield carboxylic acids • RMgX, RLi and R 2 CuLi are all strong enough nucleophiles to open epoxides α , β-Unsaturated Carbonyl Compounds (20.15) • Conjugated molecules • Contain 2 electrophilic sites • The carbonyl carbon • The β-carbon α , β-Unsaturated Carbonyl Compounds (20.15) • RMgX and RLi attack at the carbonyl carbon (1,2-addition) • Product is an allylic alcohol • R 2 CuLi reagents attack at the β-carbon (1,4-addition) • Product is a ketone or aldehyde Synthesis (20.17) • Ketones, aldehydes, alcohols (1°, 2° or 3°), alkenes, carboxylic acids and other classes of compounds can be obtained by synthetic sequences involving reactions with RMgX, RLi and R 2 CuLi...
View Full Document
This note was uploaded on 10/24/2011 for the course CHEMISTRY 623 taught by Professor Benson during the Spring '11 term at Kansas.
- Spring '11
- Organic chemistry