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Unformatted text preview: The desired trans isomer can be made using a variation of the Wittig reaction Application of the Wittig Reaction Reaction is under THERMODYNAMIC control (oxephosphetane formation is reversible, because ylide is highly stabilized by conjugation) 2 Imines (21.11) Formed in reaction between a 1 amine and an aldehyde or ketone Requires mild acidic conditions C=O converted to C=N Reaction reverses in strong acid pH-rate profile for imine formation...
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