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Unformatted text preview: Strong, bulky, non-nucleophilic base such as LDA Polar aprotic solvent Low temperature (-78 C) Factors Favoring Thermodynamic Enolate Strong base, but weaker than LDA (e.g. alkoxides) Protic solvent (allows equilibration via reprotonation/deprotonation) Room temperature (25 C) Equilibration occurs faster at higher temp. Halogenation at the -Carbon (23.7) -H can be replaced by Cl, Br or I using Cl 2 , Br 2 or I 2 as reagent Acid-catalyzed reaction allows monohalogenation Base-catalyzed reaction difficult to stop after one halogenation The iodoform test for methyl ketones Formation of a yellow precipitate (CHI 3 ) is a positive result...
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