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Unformatted text preview: α-halo carbonyl compounds (23.7C) • β-Elimination to give α , β-unsaturated carbonyl compounds • Typical reagents: Li 2 CO 3 and LiBr in DMF • S N 2 with various nucleophiles, including amines Malonic Ester Synthesis (23.9) • A way to synthesize carboxylic acids starting from the β-diester diethyl malonate, CH 2 (CO 2 Et) 2 • Sequence of reactions: • 1) Deprotonation • 2) Alkylation of enolate (two alkyl groups can be added sequentially) • 3) Hydrolysis of the ester groups and decarboxylation...
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This note was uploaded on 10/24/2011 for the course CHEMISTRY 623 taught by Professor Benson during the Spring '11 term at Kansas.
- Spring '11
- Organic chemistry