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Unformatted text preview: Examples: Crossed (Mixed) Aldol Rxn. (24.2) Crossed (Mixed) Aldol Reaction (24.2A) • Rxn. useful if only one component has α-H’s, for example: But what if you WANT one of the crossed products? Directed Aldol Rxn. (24.3) Prepare the desired enolate using LDA, then add the second carbonyl cpd. (the electrophile) Ginger Rhizome of the plant Zingiber officinale 3 Intramolecular Aldol Reaction (24.4) • Five-membered rings can be formed from 1,4-dicarbonyl compounds • Six-membered rings can be formed from 1,5-dicarbonyl compounds Claisen Reaction (24.5) • Base-promoted reaction between two esters to form a β-keto ester • An example of nucleophilic acyl substitution...
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This note was uploaded on 10/24/2011 for the course CHEMISTRY 623 taught by Professor Benson during the Spring '11 term at Kansas.
- Spring '11
- Organic chemistry