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Diabetes oral Drug chart

Diabetes oral Drug chart - Drug FBG decrea se A1C Decrease...

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Drug FBG decrea se A1C Decrease Max Effect MOA OTHER METFORMIN 50 1.5 3-4 wks Insulin sensitizer. Decreases GI glucose uptake glucose uptake Initiated @ diag. GI AE might want to titrate-take w/food. Can increase lactic acid levels— contraindicated in live dys, inc OH intake, CrCl<60, SrCr>1.5 male &>1.4 female, DX of poor oxygenation & perfusion-Lung DX, CV failure, COPD, Hypoperfusion, Renal insufficiency., >80yrs, 48hrs post radiographic dye Benefit is CHEAP, WEIGHT LOSS , NO HYPO AS MONO, PRESERVES BETA CELLS, SMALL DEC. IN TG/BP Sulfonylurea’s Secretogogs 50-80 From 9% see 2% reduction 2 wks Block SER1 on ATP K+ channel on beta cell surface, which increases insulin release. Ryan says blocks SHC pathway Cause weight gain (5-15lbs), HYPOGLYCEMIA , Rash- rare. GI-rare NEVER SKIP MEALS , OH<2drinks/day.. WORRY A BOUT B CELL BURN OUT BECAUSE WORKING AT BETA CELLS. CEASE TO WORK AFTER 4- 5 YRSS THIOZOLIDIONS —whatever PHERIPHERY INSULIN SENSATIZER— MAINLY WORKIN AT ADIPOCYTE TO INCREASE DIFERENTIATIO N. PIAGLIT ALSO WORK VIA PPAR-
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