endo_reccitation 8

endo_reccitation 8 - Growth Blood Pressure Control...

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Page 1 ENDOCRINE CONTROL OF GROWTH Introduction to GH in general, chemistry, anaphylactic shock, GHBP, bioassays, GHRH, SS, glucostats and catecholamines GH regulates protein, fat and carbo- hydrate metabolism and is regulated by proteins, FFA, glucose and other factors. GH indirect effects are mediated by liver somatomedins (IGF) Mechanism of action: GHRH, SS,GH, IGF Pubertal growth spurt in humans, an example of activation of the GH axis Pathologies: dwarfism, gigantism, acromegalia, clinical tests. GH use/abuse 25 Growth & Blood Pressure Control ENDOCRINE CONTROL OF BLOOD PRESSURE Introduction concepts to remember: a) water, glucose, mineral metabolism; b) adrenal in stress and blood pressure Renin - angiotensin (RAS) and kallikrein – kinin (KKS) systems: synthesis, secretion receptors, mechanism of action, effects Mineralocorticoids: aldosterone synthesis, secretion, receptors, mechanism of action, hormonal effects Peptide hormones and paracrine factors: ANP, BNP, CNP, ET, adrenomedullin
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endo_reccitation 8 - Growth Blood Pressure Control...

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