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Unformatted text preview: Page 1 Pathophysiology 03 • JP Advis DVM, Ph.D. Bartlett Hall, Animal Sciences, Cook, 932 - 9240, [email protected] • Course website: rci.rutgers.edu/~advis • Lectures, tests, grades, office hours, textbook, • Material to be covered: • About lecture slides: • There are not intended to be the sole source for studying the course material !!!!!!!!!!!!!!!! • Slides are good to review the course material after you have study your course textbook • Slides are a good indicator of the relative importance of lecture topics (see slide # per topic • Group slides by titles when using them to review course material. Match lectures and text. Lectures 1-2: Introduction to Pathophysiology (2) Lectures 3-4: Mechanisms of Self-Defense and Stress (2) Lectures 5-8: Endocrine and Nervous System Dysfunctions (4) Lecture 9: Alterations of Skeletal Muscle Function (1) REVIEW AND TEST #1 Lectures 12-18: Cardiovascular, Respiratory and Renal Dysfunctions (7) REVIEW AND TEST #2 Lectures 21-24: Alterations of Digestive Function and Intermediary Metabolism (4) Lectures 25-26: Alterations of the Reproductive System (2) REVIEW AND TEST #3 Defense mechanisms LINES OF DEFENSE MECHANISM: There are 2 types, innate resistance (barriers, inflammation) and the adaptive (acquired) immune system. Physical /mechanical barriers prevent damage to individual and pathogen invasion. Include skin & mucous membranes. Antibacterial peptides in mucous secretions, perspiration, saliva, tears, and other secretions are biochemical barriers. Inflammation, a rapid /non-specific response in vascularized tissues, has as its macroscopic hallmarks redness, swelling, heat, pain, and loss of function of the site. Its microscopic hallmark is accumulation of fluid and cells at the site. Adaptive immunity is a line of defense that is slower to start than innate resistance but it is specific and has a memory that makes it have a long life. It is acquired after birth, is me- diated by T and B-lymphocytes, and is initiated by innate defense signals. Adaptive immunity is active or passive de- pen-ding on its immune components origin, host or donor. Defense mechanisms line1 - barriers line2 – inflammation line3 – adaptive immunity Defense Barriers physical and mechanical biochemical barriers Inflammation the mast cells plasma protein systems cellular components cellular products manifestations resolution and repair Adaptive immunity general characteristics antigens & immunogens humoral response cell-mediated response genesis of clonal diversity induction of the response Main defense lines are barriers, inflammation and adaptive immunity Page 2 Defense Mechanisms CHARACTERISTIC INNATE IMMUNITY BARRIERS INNATE IMMUNITY INFLAMMATION ADAPTIVE (ACQUIRED) IMMUNITY Defense level First line of defense against infection and tissue injury Second line of defense (occurs as a response to tissue injury or infection) Third line of defense; becomes active when innate immune system signal cells of adaptive immunity...
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- Spring '11
- plasma protein systems