JP Advis DVM, Ph.D.
Bartlett Hall, Animal Sciences, Cook,
932 - 9240,
Course website: rci.rutgers.edu/~advis
Lectures, tests, grades, office hours, textbook,
There are not intended to be the sole source for studying the course material !!!!!!!!!!!!!!!!
Slides are good to review the course material after you have study your course textbook
Slides are a good indicator of the relative importance of lecture topics (see slide # per topic
Group slides by titles when using them to review course material. Match lectures and text.
Lectures 1-2: Introduction to Pathophysiology (2)
Lectures 3-4: Mechanisms of Self-Defense and Stress (2)
Lectures 5-8: Endocrine and Nervous System Dysfunctions (4)
Alterations of Skeletal Muscle Function (1)
REVIEW AND TEST #1
Lectures 12-18: Cardiovascular, Respiratory and Renal Dysfunctions (7)
REVIEW AND TEST #2
Lectures 21-24: Alterations of Digestive Function and Intermediary Metabolism (4)
Lectures 25-26: Alterations of the Reproductive System (2)
REVIEW AND TEST #3
HYPERSENSITIVITIES (autoimmunity, alloimmunity, allergy):
Hypersensitivity is an inappropriate immune response mis-
directed against the host’s own tissues (autoimmunity), or
directed against beneficial foreign tissues such as transfu-
sions or transplants (alloimmunity), or it can be exagerated
responses against enviromental agents (allergy). They are
classified as: type I (IgG mediated); type II (tissue specific);
type III (immune complex mediated) & type IV (cell mediated)
reactions (immediate, min / hrs, or delayed, hrs / days). The
most rapid immediate hypersensitivity reaction, anaphylaxis,
occurs within minutes of reexposure (can lead to CV shock).
Type I, Ag reacts with mast cell’s IgE & elicits degranulation.
Type II, caused by complement mediated lysis, opsonization
and phagocytosis, Ab-dependent cell-mediated cytotoxity, &
modulation of cellular function. Type III, caused by formation
of immune complexes deposited in target tissues where they
activate complement cascade, generating chemotactic frag-
ments that attract neutrophils. Type IV, caused by specifical-
ly sensitized T-cells to kill target cells directly or to release
chemokines that activate other cells, such as macrophages.
infection and injury
evaluation and care
general adaptation synd.
role of immune system
in general, and its effect
on specific endocrine
organss, as an example
Hypersensitivity is an inappropriate immune response