lecture 6 - Page 1 Pathophysiology 06 JP Advis DVM, Ph.D....

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Unformatted text preview: Page 1 Pathophysiology 06 JP Advis DVM, Ph.D. Bartlett Hall, Animal Sciences, Cook, 932 - 9240, advis@aesop.rutgers.edu Course website: rci.rutgers.edu/~advis Lectures, tests, grades, office hours, textbook, Material to be covered: About lecture slides: There are not intended to be the sole source for studying the course material !!!!!!!!!!!!!!!! Slides are good to review the course material after you have study your course textbook Slides are a good indicator of the relative importance of lecture topics (see slide # per topic Group slides by titles when using them to review course material. Match lectures and text. Lectures 1-2: Introduction to Pathophysiology (2) Lectures 3-4: Mechanisms of Self-Defense and Stress (2) Lectures 5-8: Endocrine and Nervous System Dysfunctions (4) Lecture 9: Alterations of Skeletal Muscle Function (1) REVIEW AND TEST #1 Lectures 12-18: Cardiovascular, Respiratory and Renal Dysfunctions (7) REVIEW AND TEST #2 Lectures 21-24: Alterations of Digestive Function and Intermediary Metabolism (4) Lectures 25-26: Alterations of the Reproductive System (2) REVIEW AND TEST #3 Endocrine Alterations MECHANISMS OF HORMONAL ALTERATIONS: Abnormalities in endocrine function may be caused by elevated or depressed hormone levels that result from : a) faulty feedback systems b) dysfunctions of the gland c) altered hormone metabolism d) production of hormones from non-endocrine tissues. Targets cells may fail to respond to hormones because of: a) cellsurface receptor disorders b) intracellular disorders, or c) circulating inhibitors S E Alterations in General Hypothalamus-Pituitary SIADH, diabetes insipidus, hypo and hyper pituitarism, acromegalia, prolactinoma Thyroid hyper and hypo thyroidism, carcinoma Parathyroid hyper/hypo parathyroidism Endocrine Pancreas diabetes mellitus type 1 and type 2, and complications Adrenal hyper and hypo functions Case studies Page 2 Endocrine Alterations Alterations in General Hypothalamus-Pituitary SIADH, diabetes insipidus, hypo and hyper pituitarism, acromegalia, prolactinoma Thyroid hyper and hypo thyroidism, carcinoma Parathyroid hyper/hypo parathyroidism Endocrine Pancreas diabetes mellitus type 1 and type 2, and complications Adrenal hyper and hypo functions Case studies Dysfunction of hypophysiotropic release is usually related to lesions of the pituitary stalk (2nd pituitary hypofunction). Main posterior pituitary alterations are SIADH (high ADH secretion) and Diabetes insipidus (low ADH secretion if neurogenic in origin, variable if nephrogenic in origin), Primary anterior hyperfunctions are caused by adenomas. Their expansion can cause hyposecretion of other cells, optic dysfunctions of optic chiasma, hypothalamus & cranial nerves GH hypersecretion causes acromegaly, proliferation of body / connective tissue, & renal, thyroid & reproductive dysfunction....
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This note was uploaded on 10/25/2011 for the course ANIMALSCIE 4xx taught by Professor Advis during the Spring '11 term at Rutgers.

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lecture 6 - Page 1 Pathophysiology 06 JP Advis DVM, Ph.D....

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