Page 1 Pathophysiology08 •JP Advis DVM, Ph.D. Bartlett Hall, Animal Sciences, Cook, 932 - 9240, [email protected]•Course website: rci.rutgers.edu/~advis •Lectures, tests, grades, office hours, textbook, •Material to be covered: •About lecture slides:•There are not intended to be the sole source for studying the course material !!!!!!!!!!!!!!!! •Slides are good to review the course material after you have study your course textbook •Slides are a good indicator of the relative importance of lecture topics (see slide # per topic •Group slides by titles when using them to review course material. Match lectures and text. Lectures 1-2: Introduction to Pathophysiology (2) Lectures 3-4: Mechanisms of Self-Defense and Stress (2) Lectures 5-8: Endocrine and Nervous System Dysfunctions (4) Lecture 9: Alterations of Skeletal Muscle Function (1) REVIEW AND TEST #1 Lectures 12-18: Cardiovascular, Respiratory and Renal Dysfunctions (7) REVIEW AND TEST #2 Lectures 21-24: Alterations of Digestive Function and Intermediary Metabolism (4) Lectures 25-26: Alterations of the Reproductive System (2) REVIEW AND TEST #3 Alterations of Neurologic FunctionAlterations in GeneralCNS disorders (e.g)head trauma, diffuse axonal injury, spinal cord injury, degenerative disk disease, Cerebrovascular disease ischemia with or without infarction, hemorrhage Brain infectionsmeningitis, brain abcess, encephalitis, Degenerative disordersmultiple sclerosis (MS), amio-tropic lateral sclerosis (ALS) PNS disordersplexus injuries, neuropathy, radiculopathy, Guillain-Barre Case studies Traumatic head injuries include contusion, laceration, and hematoma (extradural, subdural, intracerebral). Diffuse brain (axonal) injury results from effects of head rotation. Spinal cord injury may cause cessation of motor / sensory reflex and autonomic function below any transected area. Degenerative disk disease is an alteration of intervertebral disk tissue. Cerebrovascular disease (stroke), the most frequent neurologic disorder, include hypoperfusion, ischemia, and hemorrhage. Intracraneal aneurysms result from defects in the vascular wall. Brain infections and meningitis have multiple etiologies (bacteria, virus, fungi, and others). Brain abcesses usually originates from infections outside the CNS. Encephalitis, acute febrile state, is usually caused by arthropode-borne virus and herpes simplex virus. PNS disorders include disorders of roots of spinal cord nerves or distal to the roots (cause pain, paresthesis, paralysis). The Guillian-Barre syndrome is a degenerative disorder caused by an immuno-logic reaction to peripheral nerves. Summary examples of alterations of neurologic function
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