PROLACTIN - Prolactin Prolactin is a 199-amino acid...

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Prolactin Prolactin is a 199-amino acid polypeptide hormone secreted by lactotrophs in the anterior pituitary Factors that stimulate Prolactin release : PRH Pregnancy – due to high levels of Estrogens Nursing – nipple stimulation causes Prolactin release via a neuroendocrine reflex Dopamine antagonists Pituitary tumor Seizures Primary hypothyroidism – due to lack of the thyroid hormones, the negative feedback on TRH is absent hence, TRH levels – high levels of TRH stimulate Prolactin release. Factors that inhibit Prolactin release: PIH = Dopamine; dopamine agonists (such as Bromocriptine) Primary hyperthyroidism – causes low levels of TRH Hypophysectomy Lesions in the pituitary or in the brain
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Biological Actions of Prolactin Prolactin binds to cell surface receptors that recruit Tyrosine Kinase to : stimulate breast development/growth by synergizing with other hormones ( estrogens, progesterone, cortisol, insulin, human placental lactogen,
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