{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture0922final_1

Lecture0922final_1 - The Goldman-Hodgkin-Katz Equation Vm...

Info icon This preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
The Goldman-Hodgkin-Katz Equation 2200 ∆ V m =(RT/F) ln((P k [K] o +P Na [Na] o +P Cl [Cl] i )/( P k [K] i +P Na [Na] i +P Cl [Cl] o )) Membrane potential depends on the relative permeabilities (P) for potassium, sodium, chloride ions as well as the concentrations of those ions inside and outside the cell.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2.6 Resting and action potentials entail permeabilities to different ions.
Image of page 2
So changes in membrane potential during the action potential can be understood as being due to ion fluxes driven across the membrane ion permeability pathways (open channels). However “permeabilities” are not easy to measure – is there a simpler model? Yes – an electrical model of the cell membrane where permeabilities are replaced by electrical conductance to an ion and the Nernest potentials are represented by batteries. The membrane lipid bilayer is represented by a capacitor.
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
V m Outside cell Inside cell i leak i Na (“-ve”; i.e. into cell) i k g L (g leak ) is small – mostly due to open “leakage” potassium channels .
Image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern