Lecture0922final_1

Lecture0922final_1 - The Goldman-Hodgkin-Katz Equation Vm...

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The Goldman-Hodgkin-Katz Equation 2200 ∆ V m =(RT/F) ln((P k [K] o +P Na [Na] o +P Cl [Cl] i )/( P k [K] i +P Na [Na] i +P Cl [Cl] o )) Membrane potential depends on the relative permeabilities (P) for potassium, sodium, chloride ions as well as the concentrations of those ions inside and outside the cell.
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2.6 Resting and action potentials entail permeabilities to different ions.
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So changes in membrane potential during the action potential can be understood as being due to ion fluxes driven across the membrane ion permeability pathways (open channels). However “permeabilities” are not easy to measure – is there a simpler model? Yes – an electrical model of the cell membrane where permeabilities are replaced by electrical conductance to an ion and the Nernest potentials are represented by batteries. The membrane lipid bilayer is represented by a capacitor.
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V m Outside cell Inside cell i leak i Na (“-ve”; i.e. into cell) i k g L (g leak ) is small – mostly due to open “leakage” potassium
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Lecture0922final_1 - The Goldman-Hodgkin-Katz Equation Vm...

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