Lecture1011final

Lecture1011final - Ion pumps and transporters Pumps and...

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Ion pumps and transporters Pumps and transporters move ions hundreds of times more slowly across the membrane than do channels. Consequently, they have only a minor role in generating ion currents and determining membrane potential. But they operate continuously and can use ATP to move ions AGAINST their electrochemical (concentration gradient) So their role is to set up and maintain the ion concentration gradients that force ions through channels.
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4.10 Examples of ion transporters found in cell membranes. (Part 1)
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4.11 Mechanism of the Na + /K + pump
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4.11 Ionic movements due to the Na + /K + pump. (Part 1)
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4.13 Molecular structure of the Na + /K + pump. (Part 2)
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4.13 Molecular structure of the Na + /K + pump. (Part 1)
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4.12 Electrogenic transport of ions by the Na + /K + pump results in a minor effect on membrane potential after a burst of action potentials
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4.10 Ion exchangers (cotransporters) also transport ions and small molecules and can actively maintain certain ion gradients or transport small molecules at the expense of other ion gradients. Maintains low Ca2 + conc in cytosol using Na + gradient Re-captures NT after release at synapse Using Na + gradient
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Synaptic contact Once the action potential travels the length of the axon. It reaches the axon terminal. The axon terminal contains synaptic terminals that make contact with: the dendrites or cell bodies of other neurons or with muscle cells. At the synaptic terminals, synapses “carry” the action potential activity into the next cell. The form of the synaptic terminals is very varied. Branching at the axon terminal may allow a given neuron to make synaptic contact with more than one postsynaptic target cell A postsynaptic neuron may receive synaptic contacts from more than one
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This document was uploaded on 10/27/2011 for the course BSCI 453 at Maryland.

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Lecture1011final - Ion pumps and transporters Pumps and...

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