Lecture1018

Lecture1018 - 7.11TranscriptionalregulationbyCREB.

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7.11 Transcriptional regulation by CREB.
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Long term changes in postsynaptic cellular function due to the activation of metabotropic NT receptor proteins are often targeted towards proteins that regulate the sensitivity of the synapse to further stimulation by NT’s. This feedback modulation of synaptic sensitivity is thought to be the basis of learning and memory.
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In general, small molecule (acetylcholine, amines) NT’s can act via both ionotropic and metabotropic receptor proteins to produce both immediate and slower effects. e.g. The activation of muscle contraction by the acetylcholine-gated ionotropic receptor e.g. The decrease in heart rate via the metabotropic “muscarinic” acetylcholine receptor Peptide neurotransmitters tend to act via metabotropic receptors to produce longer term effects Gaseous neurotransmitters tend to act directly on cellular enzymes to modulate cellular messenger molecule concentrations
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Machanosensation begins with a mechanosensory receptor neuron. This neuron typically has: Its cell body in the dorsal root ganglion of the spinal cord. Its dendrites in layers of the skin (or viscera) An axon that travels up the spinal cord to make excitatatory synaptic contact with “second order” neurons in the medulla
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8.1 General organization of the somatic sensory system. (Part 1)
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The second order mechanosensory cell, with dendrites and cell body in the cuneate or gracile nucleus of the medulla, sends an axon that terminates in the ventral posterior nuclear complex of the thalamus, making an excitatory synaptic connection with a “third order” neuron.
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8.1 General organization of the somatic sensory system. (Part 1)
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The third order mechanosensory cell, with dendrites and cell body in the VPN thalamus, sends an axon that terminates in the post-central gyrus of the cerebral cortex, making contact with cerebral neurons. Thus the post central gyrus is the somosensory area of the cerebral cortex. Pain and temperature info. travels by a slightly
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This document was uploaded on 10/27/2011 for the course BSCI 453 at Maryland.

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Lecture1018 - 7.11TranscriptionalregulationbyCREB.

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