Lecture1020

Lecture1020 - Pain perception Pain Is a sensory modality...

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Pain perception Pain Is a sensory modality that is related to, but separately perceived from mechanoreception. The perception of pain does not simply arise from saturation of the response of mechanoreceptor or thermoreceptor neurons by intense stimuli. Rather…… Painful stimuli are detected by specialized high-threshold sensory neurons called nociceptors. The nociceptive pathway is a sub-division of the somatosensory pathway, involving similar, but distinct cell types
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8.3 The skin harbors a variety of morphologically distinct mechanoreceptors. Each receptor type is tuned to a particular kind of stimulation – encapsulation Mechanically filters the stimulus before it reaches the nerve ending – creating tuning Pain, temperature, crude touch Tonic, high threshold Touch pressure tonic Stretching tonic Vibration phasic Touch phasic
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9.1 Experimental demonstration that nociception involves specialized neurons. (Part 1)
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9.1 Experimental demonstration that nociception involves specialized neurons. (Part 2)
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9.2 Pain can be separated into an early perception of sharp pain and a later sensation. First, sharp pain is mediated by fast myelinated fibers, second, burning pain by small unmyelinated “C” fibers.
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Box A Capsaicin (Part 1) A subset of the small, unmyelinated “C” fibers have non-specific cation channels in their dendrites that can be opened by Capsaicin – the active ingredient of chile peppers.
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Box A Capsaicin (Part 2)
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– the primary somatosensory cortex. Note: pathway travels up
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This document was uploaded on 10/27/2011 for the course BSCI 453 at Maryland.

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Lecture1020 - Pain perception Pain Is a sensory modality...

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