Chapter_4_Cancer_Black_&_white_(Fall_2011)

Chapter_4_Cancer_Black_&_white_(Fall_2011) -...

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Chapter 4 Cancer NS6340 Shu Wang 1
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What Is Cancer? 2
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What is cancer • Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. • Cancer cells can spread to other parts of the body through the blood and lymph systems. 3
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Loss of Normal Growth Control Cancer cell division Fourth or later mutation Third mutation Second mutation First mutation Uncontrolled growth Cell Suicide or Apoptosis Cell damage— no repair Normal cell division 4
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What is cancer • Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. • Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer that begins in basal cells of the skin is called basal cell carcinoma. 5
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Different Kinds of Cancer Lung Breast (women) Colon Bladder Prostate (men) Some common sarcomas: Fat Bone Muscle Lymphomas: Lymph nodes Leukemias: Bloodstream Some common carcinomas: 6
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Naming Cancers Prefix Meaning adeno- gland chondro- cartilage erythro- red blood cell hemangio- blood vessels hepato- liver lipo- fat lympho- lymphocyte melano- pigment cell myelo- bone marrow myo- muscle osteo- bone Cancer Prefixes Point to Location 7
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Fast facts about cancer • One in three people will develop cancer. • One in four people will die of cancer. • In 2007, more than 1.5 million new cases of cancer were diagnosed. • More than 1500 Americans die of cancer each day. • Over 1,000,000 cases of skin cancer will be diagnosed this year. 8
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Top 10 cancer sites: 2007, Male, U.S. -- All race 9
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Top 10 cancer sites: 2007, Female, U.S. -- All race 10
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Major causes of death 11
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CVD deaths vs. cancer deaths 12
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Cancer Incidence Rates* by Race and Ethnicity, 2001-2005 13
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Cancer Death Rates* by Race and Ethnicity, 2001-2005 14
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Cancer Death Rates* in US 15
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U.S. death rates for common cancers: 1975-2004 16
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U.S. death rates for all cancers by race/ethnicity: 1992-2004 17
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Lifetime probability of developing or dying from cancer—Males, 2003-2005 18
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Lifetime probability of developing or dying from cancer--Females,2003-2005 19
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Trends in 5-year relative survival rates (%) in U.S. 20
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Cancer survival rates (%) by race, 1996-2004 21
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Lag Time 4000 3000 2000 1000 20-Year Lag Time Between Smoking and Lung Cancer Cigarettes Smoked per Person per Year Lung Cancer Deaths (per 100,000 people) Year Lung cancer (men) Cigarette consumption (men) 1900 1920 1940 1960 1980 150 100 50 24
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Tobacco Use in the US, 1900-2005 25
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The Biology of Cancer 26
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• Cancer is a disorder of altered cell differentiation and growth. • The resulting process is called neoplasia, and the tissue, a neoplasm. 27
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This document was uploaded on 10/27/2011 for the course NS 6340 at Texas Tech.

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Chapter_4_Cancer_Black_&_white_(Fall_2011) -...

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