311C_L14OL - DNA Structure and Function The Search for the...

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DNA Structure and Function
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The Search for the Genetic Material Structure review Functions
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Sugar-phosphate backbone Nitrogenous bases 5 end O O P O CH 2 5 4 O H H O H H H 3 1 H O CH 3 N O N H Thymine (T) O O P O O CH 2 H H O H H H H N N N H N H H Adenine (A) O O P O O CH 2 H H O H H H H H H H N N N O Cytosine (C) O O P O CH 2 5 4 O H O H H 3 1 OH 2 H N N N H O N N H H H H Sugar (deoxyribose) 3 end Phosphate Guanine (G) 2 N Figure 16.5 DNA Structure DNA is a polymer of nucleotides Nucleotides composed of three components
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What is the name of the covalent bond between nucleotides in a strand of DNA? a. Hydrogen bond b. Peptide bond c. Glycosidic linkage d. Phosphodiester bond e. Ester linkage
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Figure 16.7a, c 0.34 nm 3.4 nm (a) Key features of DNA structure 1 nm (c) Space-filling model DNA Structure Double Helix James Watson and Francis Crick (1953) (with help from R. Franklin and M. Wilkins)
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Specificity of base-pairing dictated by the structure of the bases DNA Structure Double Helix
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DNA Structure Specificity of Base-Pairing
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N H O CH 3 N N O N N N N H Sugar Sugar Adenine (A) Thymine (T) N N N N Sugar O H N H N H N O H H N Sugar Guanine (G) Cytosine (C) Figure 16.8 H DNA Structure Specificity of Base-Pairing
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O O O OH O O O O H 2 C O O O O H 2 C O O O O OH O O O T A C G C A T O O O CH 2 O O O O CH 2 CH 2 CH 2 5 end Hydrogen bond 3 end 3 end G P P P P O OH O O O O P P O O O O P O O O O P (b) Partial chemical structure H 2 C 5 end Figure 16.7b O DNA Structure Double Helix
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The structure of DNA suggested the basic mechanism for its replication “It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.” DNA Structure fits Function!
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DNA Replication: The Basic Concept (a) The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen
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This note was uploaded on 10/25/2011 for the course BIO 311C taught by Professor Satasivian during the Summer '08 term at University of Texas at Austin.

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311C_L14OL - DNA Structure and Function The Search for the...

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