BCH110A-LEC1_Intro_Water_2011

BCH110A-LEC1_Intro_Water_2011 - BIOC 110A, fall 2011...

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BIOC 110A, fall 2011 LEC 1, Introduction, Noncovalent Bonds, and Properties of Water (Dr. Ziegler © 2011) 1 Lecture 1 Introduction, Noncovalent Bonds, and Properties of Water Reading: Lehninger Principles, 5th ed.: chapter 1 (pp. 1-36) and chapter 2 (pp. 41-66) practice problems at end of BIOCHEMISTRY 110A Fall 2011 M. Ziegler Key Concepts in Biochemistry Cells -- important structural features; compartments (plasma membrane, nucleus or nucleoid, cytoplasm, ribosomes, organelles like mitochondria, chloroplasts, endoplasmic reticulum and Golgi apparatus Chemical unity of living systems Transformation of energy and matter from surroundings --> complex, orderly structures Biomolecules -- functional groups; condensation reactions Proteins -- molecular workhorses of living systems Enzymes increase rates of biological reactions to permit life on a biological timescale. Rates of processes exquisitely regulated to maintain dynamic steady state. 3-D structures of biomolecules determine their functions -- role of noncovalent interactions in structure and function.
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BIOC 110A, fall 2011 LEC 1, Introduction, Noncovalent Bonds, and Properties of Water (Dr. Ziegler © 2011) 2 Key Concepts, continued Noncovalent interactions : ionic interactions, hydrogen bonds, van der Waals interactions, hydrophobic “interactions” – individually much weaker than covalent bonds – collectively very strong crucial to structures and functions of biomolecules Properties of water -- “solvent”/milieu for living systems Most biomolecules have functional groups that are weak acids or bases – ionization properties of weak acids/bases crucial to structures and functions of biomolecules – pH determines state of ionization of biomolecular weak acids and bases. Buffers (intracellular and extracellular) Learning Objectives Review basic structures of cells and organelles -- important structural features and compartments (nucleus or nucleoid, plasma membrane, cytoplasm, ribosomes, mitochondria, chloroplasts, and endoplasmic reticulum). Review some chemistry (from posted lecture notes here): structures of functional groups important in biomolecules, and condensation reactions involving some of these functional groups. List and explain the characteristics of 4 types of noncovalent interactions important in structures and interactions of biomolecules. Answer the following questions: 1. What is an ionic interaction (charge-charge interaction), and what other terms are used to describe the same thing? How does the distance between two charged groups affect the energy of their interaction? What are the relative values of the dielectric constants for a nonpolar solvent and a polar solvent? How does solvent polarity affect strength of ionic interactions?
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BCH110A-LEC1_Intro_Water_2011 - BIOC 110A, fall 2011...

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