5-423-08ComplexLipidsStudent - Complex lipids Objectives 1...

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Complex lipids - Objectives: 1) How is cholesterol synthesized (in general)? 2) What controls cholesterol synthesis? 3) Be able to describe the functions of each of the lipoprotein types, and map the transport of cholesterol through the body
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Up to this point in the course we have discussed lipids in only two different contexts: either as a storage form of energy (triacylglycerols) or as a component of membranes (amphipathic lipids, primarily phospholipids). This is clearly an oversimplification of the functions that lipids play in metabolism and health. Wednesday we looked at the synthesis of fatty acids (FAs), key parts of many lipids. Today we will briefly discuss the synthesis of triacylglycerols (TAGs), and then concentrate on the structure, function, synthesis and transport of cholesterol. I. Review of triacylglycerols (TAGs) Structure: glycerol backbone, three FAs esterified to backbone Function: energy storage, insulation Catabolism: triacylglycerol lipase, β -oxidation II. Synthesis of TAGs Triacylglycerols are synthesized from fatty acyl–CoA and glycerol 3-phosphate. Regulation: Synthesis of storage and membrane lipids from fatty acids is determined by the metabolic needs of the organism. -Triacylglycerol synthesis is regulated by hormones; synthesis occurs when the fuel intake exceeds the energy needs of the organism. III. Cholesterol, etc. Cholesterol is a structural lipid present in the cell membranes of animals. Other sterols are found in other organisms (ergosterol in fungi, sitosterol in some plants). Cholesterol is only one of many different sterols/steroid derivatives.
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5-423-08ComplexLipidsStudent - Complex lipids Objectives 1...

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