{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

266 SN2 Slide - Review SN2 bimolecular exothermic reaction...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Review: SN2. bimolecular exothermic reaction - transition state involves I both the nucleophile and electrophile ° "“ (9,16) L. l Rem-flmte So for the rates of these reactions depend upon the following: - The Nature of the Leaving Group - - weak base Free Energy - The Reactivity of the Nucleophile All strong unhindered bases are good nucleophiles eg. CH30 6) Strong hindered bases are poor nucleophiles eg. (CH3)3CO G G) 6) Weak polarizable bases are good nucleophiles eg. I, Br Weak less polarizable bases are poor nucleophiles e.g. CH30H, H20 . The Solvent Polar aprotic #7 protic) For a SN2 reaction to proceed quickly you want to Free L J choose a solvent that make the nucleophile more energy f__ reactive. Since the nucleophile has a —ve or partial —ve (G) L“; charge polar aprotic solvents will speed up the Polar protic reaction. Polar protic solvents that hydrogen bond to the nucleophile imped the movement of the — nucleophile and stabilize the nucleophile. Ream“ °°°'di"at° 5.1 — Substitution 32 ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern