medicinal chemistry 2001-134

medicinal chemistry 2001-134 - in phase I human trials....

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r 2011 American Chemical Society 488 dx.doi.org/10.1021/ml200134s | ACS Med. Chem. Lett. 2011, 2, 488 488 IN THIS ISSUE pubs.acs.org/acsmedchemlett PET Ligands for β -Amyloid Detection Given the global scale of Alzheimer's disease, early detection of pathological processes associated with the disease such as the presence of β -amyloid plaque deposits might assist in the char- acterization of biochemical events associated with the progres- sion of cognitive decline. Early detection would also aid in the clinical evaluation of drug candidates for treating the disease. Harrison et al. (DOI: 10.1021/ml200018n) now describe a new class of radiolabeled ligands for positron emission tomography imaging (PET). One candidate PET ligand that binds β -amyloid was identi f ed by the authors and is currently under investigation
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Unformatted text preview: in phase I human trials. Calcium, Vitamin D Analogues, and Cancer Calcitriol, a form of vitamin D, shows potential antiprolifera-tive activity in several cancer cell lines due to the ability to inhibit growth. However, the therapeutic potential of this compound is severely restricted due to adverse side e F ects such as hypercalce-mia. Now, Salomon et al. (DOI: 10.1021/ml200034w) describe the design and synthesis of a calcitriol analogue that shows anti-proliferative e F ects in several cancer cell lines with diminished calcemic e F ects. The compound described by the authors is well-tolerated at relatively high doses and might serve as a starting point for a new class of anticancer compounds....
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This note was uploaded on 10/31/2011 for the course BIOENGINEE 101 taught by Professor John during the Spring '11 term at MSU Bozeman.

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