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mbi111section2notes - Mike Mesrobian MBI 111 Tuberculosis...

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Mike Mesrobian MBI 111 Tuberculosis epidemiology : Mycobacterium tuberculosis (bacterium) - 13,299 cases (and ~1300 deaths) in 2007 in the US; during the 1940s, ~100,000 cases each year (and ~40,000 deaths); there are now ~2 billion infected people worldwide, with ~8 million new cases and ~3 million deaths each year in the world . .. TB is the leading cause of death from a single identifiable infectious disease in the world as a whole, and the main cause of preventable death people ages 15-40; etiology of TB was established by Robert Koch in the late 1800s , single bacterium. Grow very slowly. pathogenesis : survives inside macrophages ; chronic lung infection leads to granuloma formation, causes poor lung function (cough, bloody sputum, pain, lack of energy, weight loss, night sweats); complications include chronic progressive lung disease, death (50% mortality without treatment) . contract by inhaling infected droplets from cough or sneeze. Sometimes called consumption. treatment
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This document was uploaded on 11/02/2011 for the course MBI 111 at Miami University.

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mbi111section2notes - Mike Mesrobian MBI 111 Tuberculosis...

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