Lecture 13 - Respiratory Drugs

Lecture 13 - Respiratory Drugs - Respiratory Drugs Chapter...

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Respiratory Drugs Asthma Medications EIB Allergies Anaphylaxis Chapter 7
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Asthma CHRONIC inflammatory disease  of the airway RECURRENT episodes of wheezing,  breathlessness, chest tightness, cough REVERSIBLE airflow obstruction Increased bronchial HYPERRESPONSIVENESS  to a variety of stimuli/triggers (examples) 4 severity stages - must know in order to tx
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How Asthma Works Bronchoconstriction of smooth mm ACUTE response Inflammation CHRONIC response Inflammatory cells release mediators which  smooth muscle contraction Inflammation sensitizes  the airways to triggers Airway remodeling  may occur
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Asthmatic Symptoms SOB Wheezing Exhalation Chest tightness Hypoxia Coughing ~ 90% of patients  diagnosed with EIB  have asthma
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Stages of Severity Mild Intermittent ≤ 2x/wk Asymp and normal  PEFR PEFR ≥80% Moderate Persistent Daily symptoms Daily use of short acting  beta2-agonist Exacerbations ≥ 2x/wk PEFR >60% - <80% Mild Persistent >2x/wk, <1x/day PEFR ≥ 80% Severe Persistent Continuous sx Frequent exacerbations PEFR ≤60%
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Treatment of Asthma 1997 NIH Guidelines Goals: Prevent chronic sx Maintain normal lung 
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  • Spring '08
  • KOLODZY
  • beta2 agonists, mast cell stabilizers, beta2 agonist Monitor, SA bronchdilator Monitor, medications Persistent asthma

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Lecture 13 - Respiratory Drugs - Respiratory Drugs Chapter...

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