Lecture 14 - Drugs for GI Disorders

Lecture 14 - Drugs for GI Disorders - Drugs for...

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Drugs for Gastrointestinal Disorders Peptic Ulcers Gastroesophageal Reflux Diarrhea Constipation
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Typical Causes of GI Upset PUD GERD Diarrhea Constipation Intestinal Gas Why do we as athletic trainers not deal with these issues on a daily basis?
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Peptic Ulcer Disease Chronic Inflammation Erosion of muscosa in stomach/duodenum Risks – age, smoking, alcohol, stress, NSAID use, history of PUD/GI bleeding Causes Helicobacter pylori NSAIDs inhibit prostaglandin synth. Hypersecretion / Zollinger-Ellison syndrome
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Drug Therapy for PUD H2 Receptor Antagonists Inhibit histimine – suppress acid secretion cimetidine (Tagamet), ranitidine (Zantac) Multiple doses are more effective AE: Diarrhea, constipation, HA, cramps, dizziness, rash Caution with renal failure/liver damage Proton-pump Inhibitors Inhibit secretion Omeprazole (Prilosec), lansoprazole (Prevacid), esomeprazole (Nexium) AE: stomach pn, HA, myalgia, angina, sedation, gas, N/V/D, rash
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