Lecture 14 - Fat soluble vitamins _JNA_-1

Lecture 14 - Fat soluble vitamins _JNA_-1 - 1 Discovery of...

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Unformatted text preview: 3/15/2010 1 Discovery of Discovery of Vitamins Vitamins Fat Fat-Soluble Vitamins Soluble Vitamins Discovery of vitamins Discovery of vitamins C. Eijkman showed that polished rice caused beriberi in chickens and non- polished rice cured the disease. Casimir Funk summarized the requirement for “vital amines” in the diet F.G. Hopkins showed that tiny amounts of certain factors from milk were necessary for the growth of rats on a purified diet. summarized the requirement for vital amines in the diet (in addition to CHO, protein and fat); postulated “ vital amine” theory of disease, i.e. certain foods could cure diseases; 4 specific “ vital amines ” ( vitamines ) would cure: pellagra, beriberi, scurvy, rickets. 3/15/2010 2 E.V. McCollum E.V. McCollum fat-soluble substance A vital amine A Vitamin A Sir Edward Mellanby Sir Edward Mellanby Cured rickets with cod liver oil. Rickets—in dogs fed an oatmeal diet and kept out of sun. Discovered the anti-rachitic substance. (Vitamin D) 3/15/2010 3 Digestion of fat Digestion of fat- soluble vitamins soluble vitamins Fat-soluble vitamins Fat-soluble vitamins require digestive enzymes for absorption The small intestine absorbs fat-soluble vitamins similarly to fat require bile acids for absorption vitamins similarly to fat absorption. Gut bacteria produce little vitamin K Retinoids Retinoids Compounds that support the physiological functions of vitamin A vitamin A = retinol retinal (visual cycle) retinoic acid (RA) All vitamin A functions (except visual cycle) 3/15/2010 4 Vitamin A (retinoids) Vitamin A (retinoids) retinal retinal vision (nyctalopia) development, growth, reproduction epithelia retinoic acid retinoic acid (skin, respiratory and digestive systems, eye xerophthalmia ) immune system nervous system i t ti carotenoids (provitamin A) vitamin A (retinol) vitamin A ester liver intestine liver storage retinoic acid (RA) RA effects RA effects reproduction reproduction nervous system nervous system epithelia (skin) epithelia (skin) immune function immune function 3/15/2010...
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This note was uploaded on 11/02/2011 for the course NST 10 taught by Professor Amy during the Spring '08 term at Berkeley.

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Lecture 14 - Fat soluble vitamins _JNA_-1 - 1 Discovery of...

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