Lecture 15 Vitamin D - Lecture 15 Vitamin D The Sunshine Vitamin Fat Soluble Vitamin With adequate sunlight there's no need for dietary Vitamin D

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Lecture 15: Vitamin D: The Sunshine Vitamin Fat Soluble Vitamin 3/17/10 With adequate sunlight, there's no need for dietary Vitamin D Regulation of Blood Calcium Primary Function of Vitamin D: maintain blood calcium concentrations Secondary function: building strong bones and teeth (deposited into bones) Bones are storehouses of calcium. 1 st job of vitamin D is to get calcium into blood Blood Calcium (9-11 mg/100 ml) is important for muscle contraction, neural transmission, blood clotting → imp. for bone structure Hypocalcemia (low blood calcium) leads to Tetany (severe contraction of muscles) → death (can kill you suddenly) Hypercalcemia leads to deposition in soft tissue (aorta malfunctions, calcium stones in kidneys) → death (takes longer to die) When sun hits skin, it reacts to form pre-vitamin D Temp. of skin converts it to vitamin D Liver converts vitamin D to 25 hydroxide vitamin D (tests for how much vitamin D you have in the doctor's office) Circulates in blood from liver. Calcitriol is responsible for physiological actions of vitamin D Must have healthy skin, liver and kidneys for everything to function well Mechanism of Calcitriol Action Calcitriol (hormone) has similar function to retinoic acid and regulates gene expression Vitamin D → calcitriol--> new cell proteins → change in cell function
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This note was uploaded on 11/02/2011 for the course NST 10 taught by Professor Amy during the Spring '08 term at University of California, Berkeley.

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Lecture 15 Vitamin D - Lecture 15 Vitamin D The Sunshine Vitamin Fat Soluble Vitamin With adequate sunlight there's no need for dietary Vitamin D

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