{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Topic 1, DNA & RNA structure

Topic 1, DNA & RNA structure - Topic 1 DNA RNA...

Info icon This preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Topic 1: DNA & RNA Structure
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Course overview What are the structures of DNA, RNA, and protein? What are the functions of DNA, RNA, and protein? What methods are available for study and manipulation of DNA, RNA, and protein? How can a cell modify it’s properties using these molecules? How does a cell control what it can do through the ability to manipulate these molecules?
Image of page 2
Learning Objectives Be able to define the following terms: nucleic acids, nucleotide vs. nucleoside, polymerization, 5’ and 3’ ends, base-pairing, anti-parallel base-pairing Be able to list the 3 components that make up nucleic acids and to identify those components in a nucleotide structure Be able to differentiate between the chemical structure and sequence of DNA and RNA Be able to identify which base is which and also which are purines and pyrimidines Be able to diagram how a nucleotide is added onto an existing nucleic acid chain Be able to label the ends (5’ vs. 3’) and strands (sense vs. antisense) of nucleic acids according to conventional rules
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Nucleotides are the building blocks of DNA and RNA O In a ring structure, if nothing is shown then typically a carbon is there
Image of page 4
(Base) (Sugar) (Phosphate) The 3 components of a nucleic acid: base, sugar, phosphate group 1 2 3 4 5 Note that the base always attaches to C 1 or the 1’ position The phosphate group attaches to the C 5 or 5’ position --Note that you will see figures that show this in the reverse orientation!
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Part 1: the base Generic Generic
Image of page 6
A denine = A bsent oxygen T hymine = T wo oxygens A ngels and G od are PURE Can never be TWO pure! Summary: Pyrimidines have a single ring and purines have 2 rings Objective: be able to identify the correct name of the molecule by looking at the structure
Image of page 7

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Bases are the most interesting part of DNA/RNA because they encode the genetic material!! Phosphate groups don’t change, although incorporated nucleotides have a single phosphate group while unincorporated nucleotides have 1, 2, or 3 groups Sugars are pretty boring except that DNA and RNA use slightly different sugars
Image of page 8
Part 2: add some sugar to make a nucleos ide Figure 1.06: Deoxy ribonucleosides: used for deoxy ribonucleic acid (DNA) Always attaches to a particular carbon atom of the sugar called the 1’ carbon
Image of page 9

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Part 3: polish if off with some phosphate to make a nucleot ide Figure 1.08a: 5'-nucleoside monophosphates Note that this structure is drawn backwards relative to slide #4.
Image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern