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Overview - pyruvate forming acetyl CoA and other products 3...

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Overview: Tissue locations Fatty acid synthesis occurs primarily in the cytoplasm of these tissues: liver adipose (fat) central nervous system lactating mammary gland Overview: Reaction sum Sum of the reactions: 8 acetyl CoA + 7 ATP + 14 (NADPH + H + ) -> palmitate (16:0) + 8 CoA + 7 (ADP + P i ) + 14 NADP + + 6 H 2 O This is the overall process for fatty acid synthesis. Acetyl CoA for fatty acid synthesis comes mostly from glycolytic breakdown of glucose. Glucose Yields Acetyl CoA -- Schematic This process is somewhat roundabout. 1. Glucose is first degraded to pyruvate by aerobic glycolysis in the cytoplasm. 2. Pyruvate is then transported into the mitochondria, where pyruvate dehydrogenase oxidatively decarboxylates
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Unformatted text preview: pyruvate, forming acetyl CoA and other products. 3. Acetyl CoA can then serve as a substrate for citrate synthesis. 4. Citrate, in turn, can be transported out of the mitochondria to the cytoplasm (where fatty acid synthesis occurs), and there split to generate cytoplasmic acetyl CoA for fatty acid synthesis. Citrate can also be oxidized by the tricarboxylic acid cycle in the mitochondria to yield energy. Notice that the need first to form citrate, then to transport it to the cytoplasm and then split it in order to get acetyl CoA for fatty acid synthesis provides several points at which control over acetyl CoA availability can be exerted....
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