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Unformatted text preview: pyruvate, forming acetyl CoA and other products. 3. Acetyl CoA can then serve as a substrate for citrate synthesis. 4. Citrate, in turn, can be transported out of the mitochondria to the cytoplasm (where fatty acid synthesis occurs), and there split to generate cytoplasmic acetyl CoA for fatty acid synthesis. Citrate can also be oxidized by the tricarboxylic acid cycle in the mitochondria to yield energy. Notice that the need first to form citrate, then to transport it to the cytoplasm and then split it in order to get acetyl CoA for fatty acid synthesis provides several points at which control over acetyl CoA availability can be exerted....
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This document was uploaded on 11/03/2011 for the course BIOLOGY BSC1105 at Broward College.
- Fall '10