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Unformatted text preview: reaction catalyzed by carnitine acyltransferase I (CAT-I), yielding CoA and fatty acyl carnitine. The resulting fatty acyl carnitine crosses the inner mitochondrial membrane. CAT-I is associated with the inner leaflet of the outer mitochondrial membrane. In liver the CAT-I reaction is rate-limiting; the enzyme is allosterically inhibited by malonyl CoA. Malonyl CoA concentration would be high during fatty acid synthesis. Inhibition of CAT-I by malonyl CoA prevents simultaneous synthesis and degradation of fatty acids....
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