Additional Enzyme1 - CoA isomerase is involved as described...

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Additional Enzymes: trans- vs cis Generating a trans- instead of a cis- double bond. If there is also a double bond at an even-numbered carbon (e.g., the second double bond in 18:2 9,12 ), the problem is to generate a trans- double bond instead of a cis- . This occurs in an indirect manner. Both activities occur in the mitochondrial matrix. FIRST: Three cycles of beta-oxidation occur normally. Beta-oxidation then continues as expected in the presence of the 9 double bond through the fourth cycle, generating a trans- double bond at the 2-position. Enoyl
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Unformatted text preview: CoA isomerase is involved, as described previously . The fourth cycle completes, and the fifth cycle then begins normally, but proceeds only through the acyl CoA dehydrogenase step. SECOND: 2,4-dienoyl CoA reductase reduces the compound, leaving one trans- double bond, but in the wrong position. NADPH + H+ is required. The product is a substrate for enoyl isomerase, the same enzyme used for cis- double bonds at odd-numbered carbons. It moves the double bond from the 3 to the 2 position. Beta-oxidation now proceeds normally....
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