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Extrahepatic tissues - CoA 3-ketoacid CoA transferase •...

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Extrahepatic tissues Ketone bodies are utilized exclusively by extrahepatic tissues; heart and skeletal muscle use them particularly effectively. If the ketone is beta-hydroxybutyrate, the first step must be reoxidation to acetoacetate, in a reversal of the reaction described previously . Acetoacetate is activated by transfer of CoA from succinyl CoA. Acetoacetate is activated by transfer of CoA from succinyl CoA in a reaction catalyzed by succinyl
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Unformatted text preview: CoA: 3-ketoacid CoA transferase. • The enzyme catalyzing this reaction is absent from liver; hence liver, which synthesizes ketone bodies, cannot use them. This places liver in the role of being a net producer of ketones. • The resulting acetoacetyl CoA can be cleaved by thiolase to form two molecules of acetyl CoA, which can then be oxidized by the tricarboxylic acid cycle....
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