Four enzymes and reaction1

Four enzymes and reaction1 - dehydrogenase reaction of the...

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Four enzymes and reactions There are four individual reactions of beta-oxidation, each catalyzed by a separate enzyme. Dehydrogenation between the alpha and beta carbons (C 2 and C 3 ) in a FAD-linked reaction. Hydration of the double bond by enoyl CoA hydratase. A second dehydrogenation in a NAD-linked reaction. Thiolytic cleavage of the thioester by beta- ketoacyl CoA thiolase. This sequence of four steps is repeated until the fatty acyl chain is completely degraded to acetyl CoA. Four enzymes and reactions: Dehydrogenation Dehydrogenation occurs between the alpha and beta carbons (C 2 and C 3 ) in a FAD-linked reaction catalyzed by acyl CoA dehydrogenase. The oxidation power of FAD is required to oxidize the alkyl chain, much as it is in the succinate
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Unformatted text preview: dehydrogenase reaction of the tricarboxylic acid cycle. The product contains a trans- double bond. Involvement of the beta-carbon in this and subsequent steps gives the pathway its name. There are three fatty acyl CoA dehydrogenases. Each is specific for a different acyl chain length, so different enzymes are involved in different stages of beta-oxidation. Long chain fatty acyl CoA dehydrogenase (LCAD) acts on chains greater than C12. Medium chain fatty acyl CoA dehydrogenase (MCAD) acts on chains of C6 to C12. Short chain fatty acyl CoA dehydrogenase (SCAD) acts on chains of C4 to C6. MCAD deficiency is thought to be one of the most common inborn errors of metabolism....
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This document was uploaded on 11/03/2011 for the course BIOLOGY BSC1105 at Broward College.

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Four enzymes and reaction1 - dehydrogenase reaction of the...

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