Four enzymes and reactions

Four enzymes and reactions - shorter than the original...

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Four enzymes and reactions: Hydration Hydration of the double bond is catalyzed by enoyl CoA hydratase. The product is an L- 3-hydroxyacyl CoA. Four enzymes and reactions: 2nd dehydrogenation A second dehydrogenation, of the alcohol, occurs in a NAD-linked reaction catalyzed by beta-hydroxyacyl CoA dehydrogenase. The product is a ketone. Four enzymes and reactions: Thiolytic cleavage Thiolytic cleavage of the thioester is catalyzed by beta-ketoacyl CoA thiolase.
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Reaction products: The products are acetyl CoA and a long chain fatty acyl CoA that is two carbons
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Unformatted text preview: shorter than the original fatty acyl CoA. The shortened fatty acyl group is now ready for another round of beta-oxidation. After the fatty acyl CoA has been reduced to acetyl or propionyl CoA, beta-oxidation is complete. Regulation: This reaction is inhibited by high concentrations of acetyl CoA. Beta-oxidation is regulated as a whole primarily by fatty acid availability; once fatty acids are in the mitochondria they are oxidized as long as there is adequate NAD + and CoA....
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Four enzymes and reactions - shorter than the original...

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