Synthesis from acetyl Co2

Synthesis from acetyl Co2 - Ketone body production is...

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Synthesis from acetyl CoA Ketone bodies are synthesized from acetyl CoA. Ketone body synthesis from acetyl CoA occurs in hepatic mitochondria. First, acetoacetate is produced in a three-step process. Acetoacetate can be reduced to beta-hydroxybutyrate. Acetone also arises in small amounts as a biologically inert side product.
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Unformatted text preview: Ketone body production is regulated primarily by availability of acetyl CoA. If mobilization of fatty acids from adipose tissue is high, hepatic beta-oxidation will occur at a high rate, and so will synthesis of ketone bodies from the resulting acetyl CoA. The rate of ketone body production increases in starvation....
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