Synthesis from acetyl CoA

Synthesis from acetyl CoA - Near-total reduction of...

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Synthesis from acetyl CoA: Acetoacetate Acetoacetate can be reduced. Subsequently acetoacetate can be reduced to beta- hydroxybutyrate by beta-hydroxybutyrate dehydrogenase in a NADH-requiring reaction. The extent of this reaction depends on the state of the NAD pool of the cell; when it is highly reduced, most or all of the ketones can be in the form of beta-hydroxybutyrate.
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Unformatted text preview: Near-total reduction of acetoacetate to beta-hydroxybutyrate can occur in severe ethanol toxicity. Synthesis from acetyl CoA: Acetone Some acetoacetate spontaneously decarboxylates to yield acetone. Some acetoacetate spontaneously decarboxylates to yield acetone. The odor of acetone can be smelled on the breath of individuals with severe ketosis....
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This document was uploaded on 11/03/2011 for the course BIOLOGY BSC1105 at Broward College.

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Synthesis from acetyl CoA - Near-total reduction of...

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