Transport and Regeneration - degraded The products of...

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Transport and Regeneration Fatty acyl CoA is impermeable to the inner mitochondrial membrane, so it is carried in the form of fatty acyl carnitine. Fatty acyl carnitine is transported across the inner mitochondrial membrane in exchange for carnitine by an antiport translocase. In the mitochondrial matrix fatty acyl carnitine reacts with CoA in a reaction catalyzed by carnitine acyltransferase II (CAT-II), yielding fatty acyl CoA and carnitine. The fatty acyl CoA is now ready to undergo beta- oxidation. overview of Mitochondrial beta-oxidation Beta-oxidation is the process by which long chain fatty acyl CoA is
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Unformatted text preview: degraded. The products of beta-oxidation are: • acetyl CoA • FADH 2 , NADH and H + The overall reaction, using palmitoyl CoA (16:0) as a model substrate: 7 FAD + 7 NAD + + 7 CoASH + 7 H 2 O + H(CH 2 CH 2 ) 7 CH 2 CO-SCoA --> 8 CH 3 CO-SCoA + 7 FADH 2 + 7 NADH + 7 H + Fate of acetyl CoA • Oxidation by the citric acid cycle to CO 2 and H 2 O. • In liver only, acetyl CoA may be used for ketone body synthesis. Fate of the FADH 2 and NADH + H + • FADH 2 and NADH + H + are oxidized by the mitochondrial electron transport system, yielding ATP....
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