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Abnormalitie2 - animal models show H2O2 is an important...

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Abnormalities Mitochondrial Myopathies o http://www.mda.org/disease/mito.html o http://www.clevelandclinic.org/health/health-info/docs/1600/1678.asp?index=6957 o http://www.genetests.org/query?dz=mt-overview Friedreich's ataxia (FRDA) o mutation in gene for frataxin (a mitochondrial iron (Fe) chaperone) o mechanism may be a mitochondrial iron (Fe) loading and reactive oxygen species
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Unformatted text preview: animal models show H2O2 is an important pathogenic substrate underlying the phenotypes arising from frataxin deficiency o Genes and Diseases - Friedreich's ataxia | • • Genes and Diseases o http://www.ncbi.nlm.nih.gov/books/bookres.fcgi/gnd/tocstatic.html • OMIM - Online Mendelian Inheritance in Man o http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim...
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