Focal Adhesions - severe skin blistering, leakage of body...

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Focal Adhesions links the outside of the cell (ECM) through transmembrane proteins (integrins) with the cell cytoskeleton (actin microfilaments) extracellular matrix integrins actin cytoskeleton Abnormalities Desmosomes pemphigus and bullous impetigo- antibodies made against one of their own desmosomal cadherin proteins antibodies bind to and disrupt the desmosomes that hold together skin epithelial cells
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Unformatted text preview: severe skin blistering, leakage of body fluids palmoplantar keratoderma Arrhythmogenic right-ventricular cardiomyopathy (ARVC) Oncogenesis not the cause but transformed cells loose adhesion, able to "break away" and spread (metastisis)....
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This document was uploaded on 11/03/2011 for the course BIOLOGY BSC1105 at Broward College.

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