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Integrins - through ECM • Mainly receptors for ECM...

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Integrins Mammals have genes for 18 alpha and eight beta integrins Role in cell adhesion to extracellular matrix (ECM) basement membranes Induction of cell polarization by adhesion Cell migration
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Unformatted text preview: through ECM • Mainly receptors for ECM proteins • Fibronectin, laminin, collagen • Some heterotypic binding Ig superfamily • Interact with cell cytoskeleton signalling...
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