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Unformatted text preview: a putative 'hairpin' intramembrane domain embedded within the membrane bilayer. The scaffolding domain, a highly conserved region of caveolin, might have a role in cholesterol interactions through conserved basic (+) and bulky hydrophobic residues (red circles). The C-terminal domain, which is close to the intramembrane domain, is modified by palmitoyl groups that insert into the lipid bilayer. The complex structures that are formed by interconnected caveolae can occupy a large area of the plasma membrane. The hypothetical formation of cubic membranes (panel e), which have adapted to allow the invagination of numerous caveolae, is depicted schematicall. These membrane invaginations can form with little energy input....
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- Fall '10