Microfilament Binding Molecules

Microfilament Binding Molecules - o Sea sponge metabolite o...

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Microfilament Binding Molecules Cytochalasin D o Fungal metabolite o Binds barbed end – inhibits polymerization and depolymerization o Cell permeant o Active in low micromolar Phalloidin o Fungal metabolite o Binds and stabilizes F-actin o Not cell permeant o Fluorescent derivatives are used to stain F-actin in situ and in vitro Jasplakinolide
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Unformatted text preview: o Sea sponge metabolite o Binds and stabilizes F-actin competitively with phalloidin o Causes nucleation o Cell permeant o Nanomolar Kd for F-actin Latrunculin o Sea sponge metabolite o Binds monomeric actin o inhibits polymerization o Cell permeant o Active at low nanomolar MF Binding Molecules...
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Microfilament Binding Molecules - o Sea sponge metabolite o...

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