B365TokT1S02 - MADE—Gila(2 3 points each IIIIIII nteme 4...

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Unformatted text preview: MADE—Gila (2- 3 points each) IIIIIII nteme 4 I 13;)_ Bit. 365' Dr TOWEWiSoar-Ii— /i’.' State three reasons why the endocrine system is Ic—onsidereti to— be— closet y linked to the nervous system. (3 points) }( How does autocrine secretion differ from paracrine secretion? (2 points) /3/. The endocrine cells of the adrenal cortex are derived from what embryological germ layer? (2 points) fit The horrrmne responsible for the production of “crop milk" in pigeons and doves is? (2 points) I j. A radioimmunoassay was used to measure the levels of circulating estradiol in three patients. The output from the radiation counter indicated that patient A's sample produced 100 counts per minute, patient B's sarnple produced 50 counts per minute. and patient C's sample produced 900 counts per minute. Which patient had the greatest amount of endogenous estradiol? (2 points) Give an example of an estrogen antagonist. (2 points) Name two GTP-binding switch proteins that are members of a GTPase super family. (2 points) myelomas and? (2 points) The method that uses a sensitive photographic emulsion to detect the anatomical lecation of )5 2./ The hybridomas used to create monoclonal antibodies are formed by the cellular fusion of 2 a radioactively labeled hormone is termed? (2 points) 10 The fact that thyroid hormone must be present in order for growth hormone to exert its full stimulatory effect on neural development is an example of what type of hormonal effect? (2 points) 1/l/ What hormone stimulates the synthesis of somatOmedins by the liver? (2 points) 1/1/ The condition that results from an excess of growth hormone synthesis in the adult human is known as? (2 points) )1 In terms of the families (categories) of andenohypohysial hormones, what other hormone belongs to the group consisting of LH and FSH? (2 points) 1;. What portion of the pituitary gland is referred to as a neumhema] organ? (2 points) L5. Alpha‘MSH is enzrnatically cleaved from the first 13 amino acids of what other pituitary hormone? (2 points) ' 16, The pituitary hormone with possible fat-mobilizing activity and from which the morphine— like substances are cleaved is? (2 points) 17. The neurohormone diat inhibits the release of proiactin is? (2 points) )4! Long—acting anaIOgs of what neurohorrnone are Used to treat acromegaly, diabetic retinopathy. and peptic ulcers? (2 points) lfif The negative feedback effect of testosterone on the release of pituitary luteinizing hormone via testosterone's action on hypothalamic GnRH-seereting cells is an example of what type of feedback loop? {2 points) ja/ What is the neurovascular hypothesis that was preposed by Geoffrey Harris? (2 points) 2’1. What is the function of the hypophysiotmpic hormones? (2 points) 32. The two magnocellular nuclei of the mammalian hypothalamus that synthesize the neurohypophysial hormones are? (2 points) Matching (4—5 points each) )3? Match die Scientists with their Discovery (5 points) A. Von Mering and Minkowski Li A; determined the structure of insulin B. Berthold .; ,2./ provided experimental evidence for the importance of the testes in male chickens Cr Bayliss and Starling 3 ac conducted a critical experiment that demostrated the presence of the hormone Secretin D. Sanger :L 47' noted the effects of removing the pancreas from dogs E. Banting and Best 5 6’. isolated insulin from the pancreas % Match the Enzyme win-i its Function. (5 points) A. protein phosphatase H. ,l’.' cleaves phosphatidyl inositol bisphosphate into 1P3 and DAG B. phosPholipase C (PLC) :1 327 protein phosphorylation C. guanylate cyclase 3 2f catalyze production of cyclic GMP D. phospholipase A2 (PLAZ) ; 44 protein dephosphorylation E. protein kinase ’1 Z pmdUCe arachidonic acid 957 Match the Hormone with its Rece tor T . (4 oints) P YPe P A. inSulin J 1/. G-protein-coupled receptor (GPCR) B. erythropoietin LI 2: receptor with tyrosine kinase activity (RTK) ' epinephrine ' 3.’ receptor with gnanylate cyclase activity C D. atrial natriuretic factor 3 A/ wrosinevkinaselinked receptor 266' Match the eicosanoid hotmOne with its biological action. (4 points) A. prostacyclin wt 4’, smooth muscle relaxation B. prostaglandin (PGEZ) 1 2'. increased vascular permeability C. thromboxane 3 .2. stimulates blood platelet aggregation D. leukotriene .2 ' A1 inhibits blood platelet aggregation Shgrt Essays (4-10 points each) 27/. Make a diagram to show how'a two—hermene negative feedback System maintains glucose homeostasis. Make sure that you include: how blood glucose levels affect hermene release, the two hormones that are involved and the endocrine cells that secrete them, and the effects of these hormones on blood glucose levels. (6 points) fl List the five classes of steroid hormones found in mammals and give a specific example of a hormone in each class. (10 points) 26. Describe how you would use an immunocytochemical assay (with the enzyme marker horseradish peroxidase) to identify the pituitaJy gland cells of the rat that synthesize growth hormone. (4 points) ' % What is the name of the calcium receptor and how doos it function? (6 points) calm-Mu IL v1 if Use a flow diagram to describe the events that occur after the activation of phOSPholipase C (PLC) in terms of the generation of second messengers. (6 points) of Make a flow diagram to illustrate the mechanism or action of the stemtd' hormone progesterone in a target cell. (6 points) )3. Draw a diagram of the vascular system that carries blood to the adenohypophysis. 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